Best Neurosurgeons in San JoseDr. Edward Rustamzadeh MD, PhD of San Jose, Ca is a highly trained, board certified, brain and spine surgeon who specializes in the treatment and diagnosis of cranial and spinal conditions as well as minimally invasive surgical techniques. Dr. Rustamzadeh is the “Surgeon to the Doctors”, having treated over 50 doctors. Dr. Rustamzadeh is considered an expert in complex spinal reconstruction and epilepsy surgery, has written several chapters in textbooks on neurosurgery and spine surgery. Dr. Rustamzadeh also specializes in treating peripheral nerve conditions as well as peripheral nerve injuries. Not only does he have comprehensive experience treating nerve injuries throughout the body, but he has just as much experience performing restorative nerve treatments from previous surgeries or procedures.

When it comes to specialists in the most advanced treatments of spinal, brain, vascular and nerve conditions, Dr. Edward Rustamzadeh of the Premier Brain and Spine Institute in San Jose, CA (Silicon Valley) is tops in the field. At Premier Brain and Spine Institute, patients receive comprehensive treatment that employs state of the art computer guided surgical equipment, advanced spinal instrumentation and endoscopic/minimally invasive keyhole brain surgery.


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Scientific Journals

  • Journal of Cellular Biochemistry (ad hoc Reviewer)


Book Chapters

  1. Rustamzadeh E, Lam C: CSF Shunts. In The Bionic Human: Health Promotion for People with Implanted Prosthetic Devices. Human Press, Totowa, NJ.
  2. Walski-Easton S, Rustamzadeh E: Stroke: Diagnosis and Management. In Essentials of Surgical Critical Care 2nd ed. Marcel Dekker, New York, NY.
  3. Rustamzadeh E, Hall WA, Todhunter D, Vallera DA: Diphtheria-based Immunotoxins: Targeting Overexpressed Interleukin-13 Receptor and Urokinase-type Plasminogen Activator Receptor on Glioblastoma Multiforme. In Cytotoxins and Immunotoxins for Cancer Therapy: Clinical Applications. CRC Press, Boca Raton, FL.
  4. Rustamzadeh E, Kawar S, Johnson JP: Fracture-Dislocations of the Thoracolumbar Spine. In Atlas of Spine Trauma. Elsevier, Burlington, MA

Professional Experience

  • 3/1/15-Present: Premier Brain and Spine Institute, Inc., San Jose, CA
  • 9/2013: Fellow of the American College of Surgeons
  • 5/2012: Diplomate of the American Board of Neurosurgery
  • 1/1/12-2/28/15: Associate Professor of Neurosurgery, Stanford University, Palo Alto, CA
  • 8/1/08-12/31/11: Assistant Professor of Neurosurgery, Stanford University, Palo Alto, CA
  • 7/1/06-7/1/08: Private Practice Orange County, CA
  • 7/1/94-8/1/95: Research Scientist, Syntex Pharmaceuticals, Palo Alto, CA


  • 9/1/14-6/31/16: Master of Business Administration, Indiana University, Kelley School of Business, Bloomington, IN
  • 7/1/05-6/31/06: Fellowship, Complex-Spine Reconstruction, Cedars-Sinai Medical Center, Los Angeles, CA
  • 7/1/01-6/31/05: Doctor of Philosophy, Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN
  • 7/1/00-6/31/05: Resident, Department of Neurosurgery, University of Minnesota, Minneapolis, MN
  • 1/1/02-9/31/02: Fellowship, Epilepsy, Minneapolis Center for Epilepsy, Minneapolis, MN
  • 6/1/99-6/31/00: Intern, Department of General Surgery, University of Minnesota, Minneapolis, MN
  • 9/1/95-5/31/99: Doctor of Medicine, Tufts University School of Medicine, Boston, MA
  • 9/1/90-6/31/94: Bachelor of Science, College of Letters and Sciences, University of California, Davis, CA
  • 9/1/87-6/31/90: High School Diploma, Leland High School, San Jose, CA
  • 6/1/89-9/1/90: Study Abroad Program, Oxford University, Oxford, UK

Academic Awards

  • Phi Beta Kappa
  • Phi Sigma Delta
  • Phi Kappa Phi
  • Golden Key
  • Presidential Academic Scholar
  • Summa Cum Laude
  • Seljeskog Neurosurgery Research Award
  • Chancellor Scholar
  • Ruth Storer Science Research Award
  • Department of Biochemistry Academic Excellence

Research Fellowships/Grants

  • NINDS Epilepsy Research Fellowship-National Institutes of Health
  • Alpha Omega Alpha Biochemistry Research Fellowship-Tufts University
  • American Heart Association Cardiovascular Research Fellowship-Stanford University


  1. Rustamzadeh E, Hall WA, Todhunter D, Vallera VD, Low WC, Liu H, Panoskaltsis-Mortari A, Vallera DA: Intracranial therapy of glioblastoma with fusion protein DTAT in immunodeficient mice. Int J Cancer 120(2):411-9, 2006.
  2. Rustamzadeh E, Todhunter D, Low WC, Liu H, Panoskaltsis-Mortari A, Hall WA, VAllera DA: Efficacy of the fusion protein DT390IL13 in an intracranial mouse model of glioblastoma multiforme. Int J Cancer 118(10):2594-601, 2006.
  3. Rustamzadeh E, Hall WA, Todhunter d, Pankoskaltsis-Mortari A, Vallera DA: Immunotoxin pharmacokinetics: a comparison of a bispecific fusion protein (DTAT13) to DTAT and DTIL13. J Neurooncol 29:1-10, 2005.
  4. Rustamzadeh E, Graupman P, Lam CH: Split brain malformation: an extension of the split cord malformation theory. J Neurosurg (Pediatrics) 104:362-365.
  5. Todhunter DA, Rustamzadeh E, Hall WA, Shu Y, Doumbia SO, Vallera DA: A bispecific immunotoxin (DTAT13) targeting human IL13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model of glioblastoma.
    Prot Eng Des Selection 17(2):157-64, 2004.
  6. Rustamzadeh E, Low WC, Vallera DA, Hall WA: Immunotoxin therapy for CNS tumor. J Neurooncol 65(1):63-75, 2003.
  7. Rustamzadeh E, Li C, Dombia S, Hall WA, Vallera DA: Targeting the overexpressed urokinase-type plasminogen activator receptor on glioblastoma multiforme. J Neurooncol 64:101-16, 2003.
  8. Hall WA, Rustamzadeh E, Asher AL: Convection-enhanced delivery in clinical trials. Neurosurgical Focus 14(2): 1-4, 2003.
  9. RustamzadehE, Truwit C, Lam C: Radiology of non-accidental trauma. Neurosurgical Clinics of North America 13:183-99, 2002.
  10. Chen JJ, Hong Y, Rustamzadeh E, Baleja JD, Androphy EJ: Identification of an alpha-helical motif sufficient for association with Papillomavirus E6 protein. J Bio Chemistry 273(22): 13537-544, 1998.
  11. Vrionis F, Robertson JT, Heilma C, Rustamzadeh E: Asterion Meningiomas. J Skull Base Surgery 8(3): 153-61, 1998.


  1. Hall WA, Rustamzadeh E, Liu H, Vallera DA: Targeting the urokinase-type plasminogen activator receptor (uPAR) on human glioblastoma with the diphtheria toxin fusion protein DTAT, Neurooncology 2002, 4:S42.
  2. Hall WA, Rustamzadeh E, Liu H, Vallera DA: Development of an anti-angiogenic targeted toxin against glioblastoma. Neurooncology 2002, 4:309.


  1. Rustamzadeh,E: Anterior Temporal Lobectomy with Amygdalohippocampectomy for Medically Refractory Epilepsy. American College of Surgeons Annual Convention October 28, 2014, San Francisco
  2. Rustamzadeh E, Vallera DA, Liu H, Low W, Hall WA: Targeting overexpressed urokinase-type plasminogen activator receptor on human glioblastoma with the diphtheria toxin fusion protein (DTAT) in nude mice. Tumor Satellite Symposium of the AANS/CNS Section on Tumors, April 11-12, 2002, Chicago.
  3. Rustamzadeh E, Vallera DA, Liu H, Low W, Hall WA: Targeting glioblastoma multiforme with an IL-13/diphtheria toxin (DTIL13) fusion protein in vivo. Immunotherapy task force meeting at the American Association of Neurological Surgeons Convention April 7, 2002.