Edward Rustamzadeh, MDDr. Edward Rustamzadeh, MD of San Jose, Ca is a highly trained spine surgeon and brain surgeon who specializes in the treatment and diagnosis of cranial and spinal conditions as well as minimally invasive surgical techniques. Dr. Rustamzadeh is the “Surgeon to the Doctors”, having treated over 50 doctors. Dr. Rustamzadeh is considered an expert in complex spinal reconstruction and epilepsy surgery, has written several chapters in textbooks on neurosurgery and spine surgery. Dr. Rustamzadeh also specializes in treating peripheral nerve conditions as well as peripheral nerve injuries. Not only does he have comprehensive experience treating nerve injuries throughout the body, but he has just as much experience performing restorative nerve treatments from previous surgeries or procedures.

When it comes to specialists in the most advanced treatments of spinal, brain, vascular and nerve conditions, Dr. Edward Rustamzadeh of the Premier Brain and Spine Institute in San Jose, CA (Silicon Valley) is tops in the field. At Premier Brain and Spine Institute, patients receive comprehensive treatment that employs state of the art computer guided surgical equipment, advanced spinal instrumentation and endoscopic/minimally invasive keyhole brain surgery.

Professional Experience

  • 3/1/15-Present: Premier Brain and Spine Institute, Inc., San Jose, CA
  • 9/2013: Fellow of the American College of Surgeons
  • 5/2012: Diplomate of the American Board of Neurosurgery
  • 1/1/12-2/28/15: Associate Professor of Neurosurgery, Stanford University, Palo Alto, CA
  • 8/1/08-12/31/11: Assistant Professor of Neurosurgery, Stanford University, Palo Alto, CA
  • 7/1/06-7/1/08: Private Practice Orange County, CA
  • 7/1/94-8/1/95: Research Scientist, Syntex Pharmaceuticals, Palo Alto, CA


  • 9/1/14-6/31/16: Master of Business Administration, Indiana University, Kelley School of Business, Bloomington, IN
  • 7/1/05-6/31/06: Fellowship, Complex-Spine Reconstruction, Cedars-Sinai Medical Center, Los Angeles, CA
  • 7/1/01-6/31/05: Doctor of Philosophy, Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN
  • 7/1/00-6/31/05: Resident, Department of Neurosurgery, University of Minnesota, Minneapolis, MN
  • 1/1/02-9/31/02: Fellowship, Epilepsy, Minneapolis Center for Epilepsy, Minneapolis, MN
  • 6/1/99-6/31/00: Intern, Department of General Surgery, University of Minnesota, Minneapolis, MN
  • 9/1/95-5/31/99: Doctor of Medicine, Tufts University School of Medicine, Boston, MA
  • 9/1/90-6/31/94: Bachelor of Science, College of Letters and Sciences, University of California, Davis, CA
  • 9/1/87-6/31/90: High School Diploma, Leland High School, San Jose, CA
  • 6/1/89-9/1/90: Study Abroad Program, Oxford University, Oxford, UK

Academic Awards

  • Phi Beta Kappa
  • Phi Sigma Delta
  • Phi Kappa Phi
  • Golden Key
  • Presidential Academic Scholar
  • Summa Cum Laude
  • Seljeskog Neurosurgery Research Award
  • Chancellor Scholar
  • Ruth Storer Science Research Award
  • Department of Biochemistry Academic Excellence

Research Fellowships/Grants

  • NINDS Epilepsy Research Fellowship-National Institutes of Health
  • Alpha Omega Alpha Biochemistry Research Fellowship-Tufts University
  • American Heart Association Cardiovascular Research Fellowship-Stanford University

Scientific Journals

  • Journal of Cellular Biochemistry (ad hoc Reviewer)


Book Chapters

  1. Rustamzadeh E, Lam C: CSF Shunts. In The Bionic Human: Health Promotion for People with Implanted Prosthetic Devices. Human Press, Totowa, NJ.
  2. Walski-Easton S, Rustamzadeh E: Stroke: Diagnosis and Management. In Essentials of Surgical Critical Care 2nd ed. Marcel Dekker, New York, NY.
  3. Rustamzadeh E, Hall WA, Todhunter D, Vallera DA: Diphtheria-based Immunotoxins: Targeting Overexpressed Interleukin-13 Receptor and Urokinase-type Plasminogen Activator Receptor on Glioblastoma Multiforme. In Cytotoxins and Immunotoxins for Cancer Therapy: Clinical Applications. CRC Press, Boca Raton, FL.
  4. Rustamzadeh E, Kawar S, Johnson JP: Fracture-Dislocations of the Thoracolumbar Spine. In Atlas of Spine Trauma. Elsevier, Burlington, MA


  1. Rustamzadeh E, Hall WA, Todhunter D, Vallera VD, Low WC, Liu H, Panoskaltsis-Mortari A, Vallera DA: Intracranial therapy of glioblastoma with fusion protein DTAT in immunodeficient mice. Int J Cancer 120(2):411-9, 2006.
  2. Rustamzadeh E, Todhunter D, Low WC, Liu H, Panoskaltsis-Mortari A, Hall WA, VAllera DA: Efficacy of the fusion protein DT390IL13 in an intracranial mouse model of glioblastoma multiforme. Int J Cancer 118(10):2594-601, 2006.
  3. Rustamzadeh E, Hall WA, Todhunter d, Pankoskaltsis-Mortari A, Vallera DA: Immunotoxin pharmacokinetics: a comparison of a bispecific fusion protein (DTAT13) to DTAT and DTIL13. J Neurooncol 29:1-10, 2005.
  4. Rustamzadeh E, Graupman P, Lam CH: Split brain malformation: an extension of the split cord malformation theory. J Neurosurg (Pediatrics) 104:362-365.
  5. Todhunter DA, Rustamzadeh E, Hall WA, Shu Y, Doumbia SO, Vallera DA: A bispecific immunotoxin (DTAT13) targeting human IL13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model of glioblastoma.
    Prot Eng Des Selection 17(2):157-64, 2004.
  6. Rustamzadeh E, Low WC, Vallera DA, Hall WA: Immunotoxin therapy for CNS tumor. J Neurooncol 65(1):63-75, 2003.
  7. Rustamzadeh E, Li C, Dombia S, Hall WA, Vallera DA: Targeting the overexpressed urokinase-type plasminogen activator receptor on glioblastoma multiforme. J Neurooncol 64:101-16, 2003.
  8. Hall WA, Rustamzadeh E, Asher AL: Convection-enhanced delivery in clinical trials. Neurosurgical Focus 14(2): 1-4, 2003.
  9. RustamzadehE, Truwit C, Lam C: Radiology of non-accidental trauma. Neurosurgical Clinics of North America 13:183-99, 2002.
  10. Chen JJ, Hong Y, Rustamzadeh E, Baleja JD, Androphy EJ: Identification of an alpha-helical motif sufficient for association with Papillomavirus E6 protein. J Bio Chemistry 273(22): 13537-544, 1998.
  11. Vrionis F, Robertson JT, Heilma C, Rustamzadeh E: Asterion Meningiomas. J Skull Base Surgery 8(3): 153-61, 1998.


  1. Hall WA, Rustamzadeh E, Liu H, Vallera DA: Targeting the urokinase-type plasminogen activator receptor (uPAR) on human glioblastoma with the diphtheria toxin fusion protein DTAT, Neurooncology 2002, 4:S42.
  2. Hall WA, Rustamzadeh E, Liu H, Vallera DA: Development of an anti-angiogenic targeted toxin against glioblastoma. Neurooncology 2002, 4:309.


  1. Rustamzadeh,E: Anterior Temporal Lobectomy with Amygdalohippocampectomy for Medically Refractory Epilepsy. American College of Surgeons Annual Convention October 28, 2014, San Francisco
  2. Rustamzadeh E, Vallera DA, Liu H, Low W, Hall WA: Targeting overexpressed urokinase-type plasminogen activator receptor on human glioblastoma with the diphtheria toxin fusion protein (DTAT) in nude mice. Tumor Satellite Symposium of the AANS/CNS Section on Tumors, April 11-12, 2002, Chicago.
  3. Rustamzadeh E, Vallera DA, Liu H, Low W, Hall WA: Targeting glioblastoma multiforme with an IL-13/diphtheria toxin (DTIL13) fusion protein in vivo. Immunotherapy task force meeting at the American Association of Neurological Surgeons Convention April 7, 2002.

Patient Reviews


"Over a period of two years and after several visits to the hospital for major heart problems resulting in 5 angiograms and 7 stents placed in his main arteries, my husband was still experiencing pain through the neck and left shoulder. The X-rays showed serious degeneration of the neck which was in the process of auto fusing. Very, very painful. Looking at the X-rays and considering his heart problems, his primary doc said there are very few surgeons that would even touch that, but one would ...Dr Rustamzadeh. After getting clearance from his cardiologist and much prayer to the Lord Jesus, two weeks later Dr R did a total reconstruction of his neck C-2 through C7. He went through the front and the back of the neck. The surgery lasted approximately 8 hours. The recovery wasn't too bad. He was off all pain meds in a week and today he is completely pain free! I can't say enough good things about Dr Rustamzadeh. He is one awesome surgeon...an absolute miracle worker!! Also, his staff is always so helpful and takes the time to answer any questions."


"I recently was referred to Dr. R for my lower back pain of over 5 years, I thought this was going to be another pat on the back saying that this is normal aging pain. After Dr. R had looked at my mri and examined me he stated I needed a outpatient surgery. Since doing the surgery the back pain that I had is gone and I'm starting to get feeling back in my toes and have been nothing but happy with this."


"Dr. Rustamzadeh was wonderful, my husband and I cannot be more grateful for his brain surgery expertise. I loved that he was pragmatic and straightforward about the process, and clear in his communication without being excessive. The surgery was very successful, quick, and professional. Highly, highly recommended."


"He did what every other doctor said couldn't be done - treated Piriformis Syndrome! I am now "free to move about the country.""


"The best Dr., surgeon & human being. My father had a back/spine surgery with him & he couldn't ask for a better Dr. than him. Kudos Dr. Edward. U deserve 7 stars."


"Dr. Rustamzadeh relieved my debilitating back pain (a stenosis--a ligament inside the spinal column gets too thick and presses on the the spinal cord--hurts like an electric jolt if you move wrong). I had read a few negative comments sprinkled among the positives about his occasional outbursts in another posting, and was prepared for some friction. However, he was a nice guy throughout. Everything he told me to do after surgery worked to relieve my post-operative pain; everything he said he would do he did; he said he would remove my pain, and he did. He was pleasant and patient with me (I always ask a lot of questions and occasionally that frustrates busy doctors). I have had 8 surgeries over 40 years, four of them on my spine, so I have met a few surgeons along the way. Rustamzadeh is easily one of the best!"


"Dr Rustamzadeh is by far the best surgeon he took care of me called to make sure I was doing ok he's my surgeon for life he is the BEST, I went to see my old surgeon about my neck :Dr Wacchhorst and after him being rude to me he said I see nothing Thank God Dr Rustamzadeh can see and read what no one else can also the radiologist who read my CT and MRI saw what no one else saw forget valley radiology and Silicon Valley radiology I go every 3 mos for test they saw nothing I went to Los Gatos El Camino Hospital and they found everythingThank God! Dr.Rustamzadeh took such good care of me I can't compare it to anyone he is Amazing and Good Samaritan Hospital was the Best, my Dr for life My Hospital for life."


"Straightforward and get the job done with no problem"


"I am writing on behalf of my husband who had surgery performed in February. He broke his neck at the C5 level. The first doctor put him in a body brace to see if things would fuse. After 2.5 months of things getting worse, he offered a 10-12 hour surgery. Then we found Doctor Rustamzedeh. He said the 2.5 months wait should never have been offered, told us he could fix things with 3-4 hour surgery and a 3-4 day hospital stay. Well, it took him 7 hours as more work was needed than what showed up on scans. If you are looking for skills, Doctor "R" is your man. If you are looking for someone to sweet talk you, he will not. He certainly cares but takes the business of healing you very seriously. For my husband, he could not have been a better choice since the surgery was not your average problem. For the money, we chose to go for expertise which he has in abundance and keep the fluff for something else. In reading other reviews, it must be pointed out that every patient must be honest with him or herself with regards to "wished for results" and "what results are possible."No doctor can undo the damage of injury. But they can set you on a course for healing and repair damage. That may or may not be the same thing as before injury. Dr R outlined what needed to be done and how things would be after surgery, in other words, what is and isn't possible. He took a severely broken neck and made it functional and my husband is feeling pretty good after the recovery time. My husband had right arm problems (paralysis) but has followed his directions to the tee (some patients don't) and we are seeing the paralysis almost gone, 3 months post surgery. Overall, my husband is very happy with his results."


"Doctor Rustamzadeh is one of the best, he is very kind and knowledgable, great staff."


"I was referred to Dr. Rustamzadeh by a family friend who recently underwent a successful complex spine surgery. Besides that, I went online to gather additional information about Dr. Rustamzadeh through others reviews from different websites. Based on the referral and many positive reviews, I decided to make a trip to his office for a consultation. After being given a thorough explanation of my spine problems and what can be done to relieve the symptoms, I set up the date for my spine surgery without hesitance. There was no intraoperative event. The pain management regimen that Dr. Rustamzadeh prescribed for me, for post-op and for discharge, was well beyond my needs. My pain, numbness, and tingling sensation have gone away; my strength has been back to normal now (about 1 month post-op). I couldnt be happier choosing Dr. Rustamzadeh as the surgeon to fix my spine problems and the related symptoms. He possesses great skills, honesty, and professionalism that one would search into for a great surgeon."


"Definitely a 5 Star Neurologist. My wife had spinal fusion, ALIF which is fusion of several discs L4/L5 L5/S1, transact decompression and...well you get the picture. It was a major 6 hour long surgery and another 4 hours in recovery at El Camino Hospital. She was in so much pain for so long prior to surgery! And as promised she has zero pain now and is so happy!!! Dr. R was very professional and thorough prior to during and post surgery. He took the time to explain things so that we understood what was going on and what we should expect. He always stopped and asked if we had questions. Of course we researched the procedures and had tons of questions that he answered even before we could ask. He was a good listener and always made sure we were fully aware of what was going on. My wife and I found Dr. R to be very compassionate and caring. He always spoke with us in a relaxed yet professional manner. HERE's an example of his compassion. When her stitches were removed and the fluids taken from her back post surgery she became weak and faint. He was so fast to take care of her to get her comfortable and make sure she was okay. I've never seen a doctor have such care and concern for a patient. That meant a lot to us. Also kudos to Nicole who is a true gem in his office. She was terrific in scheduling, insurance and especially great at getting our questions answered quickly. She deserves a raise lol! We would definitely recommend Dr. R for back issues and surgery."


"our family can not forget him, and we recommend him to every body."


"Every nurse we can into contact with said they would choose dr r if they needed surgery. There is no higher recommendation. They all loved working with dr r (so I doubt he yells at them). He contacted my husband within an hour of getting his MRI results and saw him that day. He spent another visit with him prior to the surgery. He is a man of few words because he has work to do. The nurses said he takes on the most difficult cases. We had two "issues" after the surgery and he responded to each call/question within ten minutes. One of the concerns had nothing to do with the surgery technically (a migraine) and he still helped us out. His staff was equally responsive and helpful. He is skilled, to the point, and effective. What more can you want from someone working on your spine. Thank you dr r."


"Dr. Rustamzadah gave me my life back. It have been years that I could not sleep through the night. The extreme pain in my neck is all gone. I never thought that any doctor could take my pain away. Dr. Rustamzadeh performed a successful surgery. Thank you so much."


"He is the best. I had a low back fusion. I am pleased with the results. He answered all my questions and his office staff is very helpful. I would not hesitate sending family and friends to him."


"I recently had a complex spinal surgery performed by Dr. Rustamzadeh, with a better than expected outcome. He was thorough in answering questions pre- and post op, was kind and concerned. I am very pleased with my choice of surgeons."


"Dr Edward Rustamzadeh is like god to me . He is not the chatty type, he is very knowledgeable as we'll diligent neuro surgeon . His way is process of elimination to troubleshoot the exact problem I had made me very comfortable with surgery as my decision. First of all - I don't get these negative reviews , it takes a lot to be the best surgeon for Stanford . I know that I will be feeling good soon as I recover ,as my surgery was a week ago .I have called numerous times to his office and they are outstanding in follow up which is very important to have a good office staff. To be exact David was above and beyond including his co worker's name I don't remember . Thank you all for your hardwork and Iwill recommend dr Rustamzadeh for anyone that needs surgery. I'm going in for a back surgery soon, And will definitely be coming back . Thank you all God bless."


"Did surgery on my back and relieved my leg pain instantly. Was back to work the following week. I dont care what the other commenters say "he is a top notch surgeon in my book"."


"Dr. Rustamzadeh was amazing with the back surgery for my husband. We would highly recommend Dr. Rustamzadeh and his staff is very caring and helpful. My husband was up and walking following the very successful surgery."


"Prior to Dr. Rustamzadeh's, over the last 60+ years I've had four surgeries under general anesthesia, one an open-heart aortic valve replacement. Dr. Rustamzadeh performed a three-hour (exactly as he forecasted) microscopic (not endoscopic) bilateral lumbar laminotomy in six locations on my spine at Good Sam ~ a month ago. First and foremost, I can walk again - upright. My legs actually do what I tell them. I can sneeze and cough without being driven to my knees in agony. I am pain-meds free (prescription and OTC) for the first time in years. Not helping with my pre-op anxiety, prior to my surgery I read an uncomplimentary review regarding Dr. Rustamzadeh but chose to go forward as my cardiologist/PCP is batting 1.000 with his referrals as well as my previous positive experiences with Stanford doctors/surgeons. Because my awesome results speak for themselves, I wouldn't have cared if Dr. Rustamzadeh were Dr. Frank Burns from M.A.S.H. I spent one night in Good Sam, which, by the way, was an excellent experience - staff is wonderful in pre-op testing, morning pre-op preparation and post-op care. During my brief stay as a no-risk/no-complications patient, Dr. Rustamzadeh dropped by no less than three times assessing my condition and issuing change orders as necessary. After my release, twice my wife called the Dr. through the office/exchange with questions. Within a half-hour she had her answer to one (on a surgery day, no less!) and actually spoke with Dr. Rustamzadeh very late one night for another (we thought) more pressing issue. So far, I've had three office visits during which I was seen either on time or early. Is Dr. Rustamzadeh bedside chit-chatty? Nope. He doesn't appear to have too much time for that. He is efficient, quick, experienced, knowledgeable and communicates well with laymen on an understandable level. More importantly, did he change my life and my outlook for the future? Yes. And the real acid test: my (2x cancer survivor) wife was happy with our experience."


"Awesome doctor and gave me a new life."


"I can't wait to get back right was some what curt but better than initial visit."


"Everything they are doing is great. Wait times were minimal, front office was very welcoming and accommodating to my mothers needs."


"When everything goes better than planned, it means that perfection for us has been achieved."

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Doctor Rating

5.0 out of 5

Edward Rustamzadeh, MD

42 Patient Ratings
27 Patient Comments

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